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10.1073/pnas.74.12.5547 126 CrickS

The high degradation efficiency of DJX-A-KM likely results from the simple acrylamide warhead, which possesses moderate electrophilicity and minimal steric hindrance, preserving the MRTX849 scaffolds binding to KRAS G12C while facilitating effective recruitment of degradation machinery

For example, an early wound study measured changes at days 4 and 7

Tsunemi T, Ishiguro Y, Yoroisaka A et al (2020) Astrocytes protect human dopaminergic neurons from -synuclein accumulation and propagation

Immune reactions: The body may recognize synthetic peptides as foreign, triggering allergic or autoimmune responses